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Citation
TSAI, I., CROFT, K.D., MORI, T.A., FALCK, J.R., BEILIN, L.J., PUDDEY, I.B. & BARDEN, A.E. (2009). 20-HETE and F2-isoprostanes in the metabolic syndrome: the effect of weight reduction. Free Radical Biology and Medicine, 46(2), 263-270.
Title
20-HETE and F2-isoprostanes in the metabolic syndrome: the effect of weight reduction
Author
Year
2009
Published in
Abstract
20-Hydroxyeicosatetraenoic acid (20-HETE) is a cytochrome P450 metabolite of arachidonic acid that regulates vascular function and sodium homeostasis. Studies showing an association between 20-HETE excretion, raised BMI, and oxidative stress suggest that 20-HETE may be important in the development of cardiovascular disease in the metabolic syndrome (MetS). We investigated whether 20-HETE and F2-isoprostanes (markers of oxidative stress) were altered in the MetS before and after weight reduction. A case-controlled comparison of 30 participants with the MetS and matched controls showed that plasma and urinary 20-HETE and F2-isoprostanes were significantly elevated in the MetS group. There was a significant gender × group interaction such that women with the MetS had higher urinary 20-HETE and F2-isoprostanes compared to controls (p < 0.0001). In a randomized controlled trial, 42 participants with the MetS were assigned to 16 weeks of weight maintenance or a 12-week weight-loss program followed by 4 weeks weight stabilization. Relative to the weight-maintenance group, a 4-kg loss in weight resulted in a 2-mm Hg fall in blood pressure (BP) but did not alter urinary or plasma 20-HETE or F2-isoprostanes. 20-HETE and oxidative stress may be important mediators of cardiovascular disease risk in the MetS. Although a 4% reduction in body weight reduced BP, there were no changes in plasma or urinary 20-HETE or F2-isoprostanes.
Identifier
http://dx.doi.org/10.1016/j.freeradbiomed.2008.10.028
Identifier
TSAI, I., CROFT, K.D., MORI, T.A., FALCK, J.R., BEILIN, L.J., PUDDEY, I.B. & BARDEN, A.E. (2009). 20-HETE and F2-isoprostanes in the metabolic syndrome: the effect of weight reduction. Free Radical Biology and Medicine, 46(2), 263-270.
Identifier
0891-5849
Identifier
http://repository.uwa.edu.au:80/R/-?func=dbin-jump-full&amp;object_id=27385&amp;silo_library=GEN01
ISBN/ISSN
0891-5849
Subject
Department/School
Type
Journal article
Additional Information
Link to Publisher's website supplied in Alternative Location.
Alternative Location
DOI
Persistent URL
http://repository.uwa.edu.au:80/R/-?func=dbin-jump-full&amp;object_id=27385&amp;silo_library=GEN01
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